Relationship of Potential İnflammatory Markers Namely Neutrophile Lymphocyte Ratio and Platelet Lymphocyte Ratio with The Severity of Obstructive Sleep Apnea

Oğuz Dikbaş, Nilgün Erten, Fatma Küçüker, Özge Yılmaz Akşehirli


Aim: The aim of the present study is to evaluate hematological parameters in patients with obstructive sleep apnea syndrome (OSAS).
Material and Methods: Patients underwent a polysomnographic (PSG) test at our sleep laboratory was retrospectively reviewed.
Patients with cancer, cardiovascular disease, hematologic disorders, infectious diseases and rheumatologically disorders, renal or
hepatic insufficiency were excluded from the study. Two hundred and ten OSAS patients with an apnea-hypopnea index (AHI) of more
than five events and 57 controls with an AHI of less than four events were included. Study population was divided into four groups
depending on the AHI as: mild OSAS (AHI= 5-15), moderate OSAS (AHI=15-30), severe OSAS (AHI>30), and the control (AHI<5).
Hematologic parameters were measured and compared.
Results: Platelet lymphocyte ratio was significantly lower in patients with OSAS compared to the control (p = 0.050). Neutrophil
lymphocyte ratio between OSAS and the control was not different (p = 0.947). Serum triglyceride level and mean platelet volume were
significantly higher in patients with OSAS (p < 0.0001; p = 0.043). Platelet distribution width was significantly higher in severe OSAS
group compared to control, mild and moderate OSAS subgroups (0.014).
Conclusion: No relationship was found between OSAS and NLR. There is a debate over putative relationship between NLR, PLR, and

Anahtar Kelimeler

Obstructive sleep apnea syndrome, OSAS, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio

Tam Metin:




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